李　霞，博士、研究員，博士生導師 1985-1995年在河北師范大學生物系獲得理學學士和植物生理學碩士學位，并留校任講師。1995-2001在美國Purdue University生物系和園藝系工作和學習，獲得博士學位。2001-2004年在美國Vector Tobacco公司任科學家和課題組長。2004年入選中國科學院“百人計劃”，回遺傳與發(fā)育生物學研究所石家莊農業(yè)資源研究中心工作。 研究方向 1、植物抗逆分子機制的研究 植物對逆境響應以及抗逆的分子機制是一個重要的生物學問題，涉及到植物在逆境下的可塑性發(fā)育、基礎代謝以及植物細胞、組織和個體得能量、水分、離子、氧化還原物的穩(wěn)態(tài)的調控等生物學過程。本課題組的研究方向是高等植物逆境生理和分子遺傳學。主要包括模式植物擬南芥、小麥和大豆在非生物逆境尤其抗鹽堿、干旱和低溫條件下的生理和遺傳機理。重點是植物根系發(fā)育對逆境適應和調控分子網絡，逆境條件下植物防御代謝的轉換的機制，以及植物生理節(jié)水的遺傳學基礎。最終目標是揭示植物抗逆的分子機理，用遺傳轉化手段創(chuàng)建抗鹽堿和抗旱節(jié)水新作物品系。 2、大豆固氮效率調控機理的研究 大豆是重要的經濟作物，是植物蛋白和油脂的主要來源。大豆可以和根瘤菌共生形成根瘤，進而把空氣中的N2轉化為植物可以利用的NH3。大豆根瘤的發(fā)育和固氮效率的高低是影響大豆高產優(yōu)質的關鍵因素，二者對環(huán)境脅迫非常的敏感。本課題組利用反向遺傳學以及轉基因等方法對大豆根瘤發(fā)育和固氮效率對非生物脅迫響應的分子機制進行系統(tǒng)性研究。重點研究大豆miRNA及靶基因影響大豆根瘤發(fā)育和固氮效率的分子調控網絡。 發(fā)表文章（* 通訊作者） Wang Y, Li K, Chen L, Zou Y, Liu H, Tian Y, Li D, Wang R, Zhao F, Ferguson B, Gresshoff P, Li X*. (2015) MicroRNA167-directed regulation of the auxin response factors, GmARF8a and GmARF8b, is required for soybean (Glycine max L.) nodulation and lateral root development. Plant Physiology DOI:10.1104/pp.15.00265. Wang Y, Wang L, Zou Y, Chen L, Cai Z, Zhang S, Zhao F, Tian Y, Jiang Q, Ferguson B, Gresshoff P, Li X*. (2014) Soybean miR172c targets the repressive AP2 transcription factor NNC1 to activate ENOD40 expression and regulate nodule initiation. Plant Cell 26: 4782-4801. Ji H, Wang S, Li K, Szakonyi D, Koncz C, Li X*. (2014) PRL1 modulates root stem cell niche activity and meristem size through WOX5 and PLTs in Arabidopsis. Plant Journal 81: 399-412. Ji H, Liu L, Li K, Xie Q, Wang Z, Zhao X, Li X*. (2014) PEG-mediated osmotic stress induces premature differentiation of the root apical meristem and outgrowth of lateral roots in wheat. Journal of Experimental Botany 65: 4863-4872. Kong D, Li M, Dong Z, Ji H, Li X*. (2014) Identification of TaWD40D, a wheat WD40 repeat-containing protein that is associated with plant tolerance to abiotic stresses. Plant Cell Report 34: 395-410. Zhang S, Wang Y, Li K, Zou Y, Chen L, Li D, Cai Z, Wang L, Wang R, Wang Y, Li X*. (2014) Uncovering miRNA-mediated responses to low temperature in nitrogen-fixing nodules of soybean. International Journal of Molecular Sciences 15: 13596-13614. Liu L, Guo G, Wang Z, Ji H, Mou F, Li X*. (2014) Auxin in plant growth and stress responses. In: Lam-Son Phan Tran and Sikander Pal (eds). Phytohormones: A window to metabolism, signaling and biotechnological application. Springer Science, New York, USA, pp1-35. Li D, Liu H, Qiao Y, Wang Y, Cai Z, Dong B, Shi C, Liu Y, Li X, Liu Mengyu. (2013) Effects of elevated CO2 on the growth, seed yield, and water use efficiency of soybean (Glycine max (L.) Merr.) under drought stress. Agricultural Water Management 129: 105-112. Zou Y, Wang Y, Wang L, Yang L, Wang R, Li X*. (2013) miR172b controls the transition to autotrophic development inhibited by ABA in Arabidopsis. PLoS ONE 23: e64770. Luo Y, Wang Z, Ji H, Fang H, Wang S, Tian L, Li X*. (2013) An Arabidopsis homolog of importin beta 1 is required for ABA response and drought tolerance. Plant Journal 75: 377-389. Dong Z, Shi L, Wang Y, Chen L, Cai Z, Wang Y, Jin J, Li X*. (2013) Identification and dynamic regulation of microRNAs involved in salt stress responses in functional soybean nodules by high-throughput sequencing. International Journal of Molecular Sciences 14: 2717-2738. Peng Y, Ma W, Chen L, Yang L, Li S, Zhao H, Zhao Y, Jin W, Li N, Bevan MW, Li X, Tong Y, Li Y. (2013) Control of root meristem size by DA1-related protein 2 in Arabidopsis thaliana. Plant Physiology 16: 1542-1556. Zhao H, Liu L, Mo H, Qian L, Cui S, Li X, Ma L. (2013) The ATP-binding cassette transporter ABCB19 regulates postembryonic organ separation in Arabidopsis. PLoS ONE 8: e60809. Ji H, Pardo JM, Batelli G, Van Oosten MJ, Bressan RA, Li X*. (2013) The salt overly sensitive (SOS) pathway: established and emerging roles. Molecular Plant 6: 275-286. Zhao H, Wang X, Zhu D, Cui S, Li X, Cao Y, Ma L. (2012) A single amino acid substitution in IIIf subfamily of basic Helix-Loop-Helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis. Journal of Biological Chemistry 287: 14109-14121. Hao L, Wang W, Chen C, Wang Y, Liu T, Li X, Shang Z. (2012) Extracellular ATP promotes stomatal opening of Arabidopsis thaliana through heterotrimeric G protein a subunit and reactive oxygen species. Molecular Plant 5: 852-864. Zhao Y, Wang T, Zhang W, Li X*. (2011) SOS3 mediates lateral root development under low salt stress through regulation of auxin redistribution and maxima in Arabidopsis. New Phytologist 189: 1122-1134. Cao M, Li X*. (2010) Die for living better: Plants modify root system architecture through inducing PCD in root meristem under severe water stress. Plant Signaling & Behavior 5: 1-2. Orsini F, D'Urzo MP, Inan G, Serra S, Oh DH, Mickelbart MV, Consiglio F, Li X, Jeong JC, Yun DJ, Bohnert HJ, Bressan RA, Maggio A. (2010) A comparative study of salt tolerance parameters in 11 wild relatives of Arabidopsis thaliana. Journal of Experimental Botany 61: 3787–3798. Zhao Y, Wang T, Zhang W, Li X*. (2010) The role of auxin in plastic development of plant root system architecture in response to abiotic stimuli. Plant Nutrition and Abiotic Stress Tolerance. Global Science Books. Isleworth, UK, pp19-32. Zhao Y, Wang T, Zhang W, Li X*. (2010) SOS3 mediates lateral root development under low salt stress through regulation of auxin redistribution and maxima in Arabidopsis. New Phytologist 189: 1122-1134. Duan Y, Zhang W, Li B, Wang Y, Li K, Sodmergen, Han C, Li X*. (2010) An ER response pathway mediates programmed cell death of root tip induced by water stress in Arabidopsis. New Phytologist 186: 681-95. Xu J, Yin H, Liu X, Li X*. (2010) Salt affects plant Cd-stress responses by modulating growth and Cd accumulation. Planta 231: 449-59. Xie Q, Yan X, Liao X, Li X*. (2009) The arsenic hyperaccumulator fern Pteris vittata L. Environmental Science & Technology 43: 8488-8495. Xu J, Yin H, Li X*. (2009) Protective effects of proline against cadmium toxicity in micropropagated hyperaccumulator, Solanum nigrum L. Plant Cell Reports 28: 325-33. Wang Z, Li X*. (2009) IAN/GIMAPs are conserved and novel regulators in vertebrates and angiosperm plants. Plant Signaling & Behavior 4: 1-3. Wang Y, Li K, Li X*. (2009) Auxin redistribution modulates plastic development of root system architecture under salt stress in Arabidopsis thaliana. Journal of Plant Physiology 166:1637-1645. Wang Y, Li P, Cao X, Wang X, Zhang A, Li X*. (2009) Identification and expression analysis of miRNAs from nitrogen-fixing soybean nodules. Biochemical and Biophysical Research Communications 378: 799-803. Quist T, Sokolchik I, Shi H, Joly R, Bressan R, Maggio A, Narsimhan M, Li X*. (2009) HOS3, an ELO-Like gene, inhibits effects of ABA and implicates a S-1-P/Ceramide control system for abiotic stress responses in Arabidopsis thaliana. Molecular Plant 2: 138-151. Xu J, Yin H, Wang W, Mi Q, Liao X, Li X*. (2009) Identification of Cd-responsive genes of solanum nigrum seedlings through differential display. Plant Molecular Biology Reporter 27: 563-569. Wang X, Gao Z, Wang Y, Bressan RA, Weller SC, Li X*. (2009) Highly efficient in vitro adventitious shoot regeneration of peppermint (Mentha x piperita L.) using internodal explants. In Vitro Cellular & Developmental Biology- Plant 45: 435-440. Manabe Y, Bressan R, Wang T, Li F, Koiwa H, Sokolchik I, Li X*, Maggio A*. (2008) The Arabidopsis kinase-associated protein phosphatase regulates adaptation to Na+ stress. Plant Physiology 146: 612-622. Sun F, Zhang W, Hu H, Li B, Wang Y, Zhao Y, Liu M, Li X*. (2008) Salt modulates gravity signaling pathway to regulate growth direction of primary roots in Arabidopsis thaliana. Plant Physiology 146:178-88. Wang Y, Zhang W, Li K, Sun F, Han C, Wang Y, Li X*. (2008) Salt-induced plasticity of root hair development is caused by ion disequilibrium in Arabidopsis thaliana. Journal of Plant Research 121: 87-98. Wang Y, Li X*. (2008) Salt stress-induced cell reprogramming cell fate switch and adaptive plasticity during root hair development in Arabidopsis. Plant Signaling & Behavior 3: 436 -438. Li X*, Zhang W. (2008) Salt-avoidance tropism in Arabidopsis. Plant Signaling & Behavior 3: 351-353. Liu C, Wang T, Zhang W, Li X*. (2008) Computational identification and analysis of immune-associated nucleotide gene family in Arabidopsis thaliana. Journal of Plant Physiology 165: 777-787. Wang Y, Wang T, Li K, Li X*. (2008) Genetic analysis of involvement of ETR1 in plant response to salt and osmotic stress. Plant Growth Regulation 54: 261-269. Li K, Wang Y, Han C, Zhang W, H Jia, Li X*. (2007) GA signaling and CO/FT regulatory module mediate salt-induced late flowering in Arabidopsis thaliana. Plant Growth Regulation 53: 195-206. Inan G, Goto F, Jin J, A Rosado, Koiwa H, Shi H, Hasegawa PM, Bressan RA, Maggio A, Li X*. (2007) Isolation and characterization of shs1, a sugar-hypersensitive and ABA-insensitive mutant with multiple stress responses. Plant Molecular Biology 65: 295-309. Wang Y, C Liu, K Li, F Sun, H Hu, Li X*. (2007) Arabidopsis EIN2 modulates stress response through abscisic acid response pathway. Plant Molecular Biology 64: 633-644. Zhang W, Li X, Liu JB. (2007) Genetic variation of Bmy1 alleles in barley (Hordeum vulgare L.) investigated by CAPS analysis. Theoretical Applied Genetics 114: 1039-1050.