18th,?Sept,?2018?13:00-17:30?會前會

DNA?甲基化專題研討會

會議注冊

DNA?甲基化在皮膚病研究中的進（TBD）

DNA?甲基化在液體活檢中的應用

柳娜?博士（馬駿教授團隊）

中山大學腫瘤防治中心

茶歇

Epigenome-wide?association?study?

identifies?Behcet's diseaseassociated

methylation?loci?in?Han?Chinese

李明輝?博士

表觀星圖計劃首席科學家

中科普瑞科研服務技術產品總監(jiān)

朱景德、張學軍、柳娜、

于紅松、戴珩、李明輝

19th,?Sept,?2018

Opening

I.?Chemical?and?Biological?Perspectives?of?DNA?Modifications

Chair?of?the?first?half?part:?Kazu?Ushijima?(Tokyo)

Guoliang?Xu

?(Academia?Sinica,Shanghai)

Aging,?epigenetic?clocks?and?cancer?risk

Active?DNA?Demethylation?by?Vertebrate

?DNA?Methyltransferases

James?Shen?

(AcademiaSinica,Taipei)

The?DNA?modification?landscape?of?human

?genome：?anexperience?of?HuaXia1?genome/

Third-Generation?Sequencing.

Depeng?Wang?

（GrandomicsBiosciences）

N6-Methyladenine?DNA?Modification?

in?the?Human?Genome

Chuanle?Xiao?(ZhongshanOphthalmic?

Center,?Sun?Yat-sen?University)

Break+Group?Photograph

Chair?of?the?second?half?part?:?Fei?Lan

(FuDan?University)

Structural?Insight?into?dynamic?regulation?of?DNA?

methylation

DNA?5-Hydroxymethylcytosines?from?Cell-free?Circulating?DNAasDiagnostic?Biomarkers?

for?Human?Cancers

Bisulfite-free,?nano-scale?analysis?of?5-hydroxymethylcytosine

?atsingle?base?resolution.

BRIF-seq:?bisulfite-converted?randomly?integrated?

fragmentssequencing?at?single?cell?level

Xiang?Li

(HuazhongAgricultural?University)

The?role?of?differentially?methylated?regions?in

?normalhematopoiesis?and?leukemogenesis

Lunch

Poster?session?Chair:?Guohong?Li

Decoding?the?epigenetic?landscape?by?the?

histone?readers:implications?in?human?diseases

Epigenome?reprogramming?as?a?basis?for?

combination?therapy

II.Chemical?and?Biological?Perspectives?of

?histone?modifications

Chair?of?the?first?half?part?:?Youngjun?Kim(Korea,?Seul)

Structure?and?function?of?yeats?domain?in

?health?and?disease

Haitao?Li

(TsinghuaUniversity)，

Fei?Lan?

(Fudan?University)

Ullas?Kolthur-Seetharam

（Tata?Institute，?India）

Metabolic?regulation?of?gene?expression

Tea?Break

Chair?of?the?second?half?part:?Lijung?Juan

(Academia?Sinica,?Taipei)

Epgenetics?and?Adipogenesis:?Implications?of

?HistonemodificationsLanguages

UTX?functions?as?an?escape?from?X-inactivation?

tumor-suppressorin?B?cell?lymphoma

Hai?Jiang

（Academica?Sinica,Shanghai）

Xiuyan?Yang?(Shanghai?JiaoTong

?University?School?ofMedicine)

20th,?Sept,?2018

III.?Chemical?and?epigenetic?regulation?of?transcription

Chair?of?the?first?half?part:?Shyam?PRABHAKAR

?(Singapore)

R-loopsin?physiology?and?pathology

Epigenetic?Regulation?of?Hematopoietic?Stem

?Cell?Development

The?Diversity?and?Function?of?Long?Noncoding?

RNAs

Lingling?Chen

(AcademiaSinica,Shanghai)

Cis-acting?lncRNAs?in?transcription?and?chromatin

?regulation

Xiaohua?Shen

(TsinghuaUniversity)

Tea?Break

Chair?of?the?second?half?part:?Hongkui?Deng

(Peking?University)

R-loop,?the?general?chromatin?feature

?in?Arabidopsis?genomes

Zefeng?Wang

(AcademiaSinica，Shanghai)

A?long?noncoding?RNA?in?telomere?maintenance,?

gene?regulationandinter-chromosomal?pairing

Hsueh-Ping?Chu

(NationalTaiwanUniversity)

Single-cell?Landscape?during?Cell-fate?conversion

Lunch

Short-talks?Chair：?Yanhui?Xu

A?new?layer?of?rRNA?regulation?by?small?

interference?RNAs?andthe?nuclear?RNAi?pathway

Shouhong?Guang?(Universityof

?Science?and?Technology?ofChina)

m6A?methyltransferase?complex?regulates?

hematopoietic ste-mcell?selfrenewal?in?

the?bone?marrow

RNA?m6A?Modifications?in?T?Cell?Differentiation?

and?Inflammation

Huabing?Li?(Shanghai?JiaoTong?

University?School?ofMedicine)

Function?and?mechanism?of?2OG-oxygenase?JMJD6?in?breastcarcinogenesis

IV.Clinical?Epigenetics

Chair?of?the?first?half?part?:?Tapas?Kundu(India)

Implication?of?Long?Non-coding?RNAs?in

?Cancer?Biology

Global?transcriptional?memory?is?mediated?by?

H3K4me3-Rpd3LHDAC?pathway

Whole-genome?and?epigenomic?landscapes?of?

etiologicallydistinctsubtypes?of?cholangiocarcinoma

Teh?Bin?Tean

?(CancerCenter,Singapore),

Functional?prediction?of?causal?regulatory

?variants?identifies?anovelautism?gene

Jung?Kyoon?Choi?(Korea)

Tea?Break

Chair?of?the?second?half?part:?Zefeng?Wang

(Academia?Sinica)

Histone?acetylome-wide?association?study?identifies?epigenetic

changesand?a?protective?host?response

?mechanism?to?infection

Characterization?of?interaction?modes?between?the

?BRMbromodomain?and?inhibitors?in?

the?limit?of?NMR?intermediateexchange

Ke?Ruan（University?of?Scienceand?

Technology?of?China）

Biochemical?studies?and?molecular?dynamic?

simulations?reveal?themolecular?basis?of?

conformational?changes?in?

dnamethyltransferase-1?(dnmt1)

Shijie?Chen

(Academia?Sinica,Shanghai）

Drug?discovery?of?protein-protein?interactions

?by?targeting?epi-modification?

sites?of?untargetable?protein

Wenchao?Lu

(?Academia?Sinica,Shanghai)

21st,?Sept,?2018

V.Chemical?and?biological?perspectives?of?the?higher-orderchromatin?structure

Chair?of?the?first?half?part:?Young-Joon?Kim(Korea)

Crosstalk?between?histone?modifications

?duringheterochromatinassembly

Jun-ichi?Nakayama

(Tokyo，Japan)

Dynamic?regulation?of?higher-order?

chromatin?structures?ingeneregulation

Guohong?Li

?(AdademiaSinica,Beijing)

Reprogramming?of?chromatin?architecture

?in?earlymammaliandevelopment

Wei?Xie

?(Tsinghua?University)

Combinatorial?mechanisms?in?3D?genome?

folding?andtranscriptionregulation

Yijun?Ruan

?(Jackson?Lab,USA)

Tea?Break

Chair?of?the?second?half?part:?Lingling?Chen

(Academia?Sinica,Shanghai)

Systematic?Mapping?of?RNA-Chromatin?Interactions?In?Vivo

Sheng?Zhong?

(UCSD)

Multisite?substrate?recognition?in?Asf1-dependent

?acetylation?ofhistone?H3?K56?by?Rtt109

Lin?Zhang?

(?Academia?Sinica,Beijing)

3D?Genome?of?Multiple?Myeloma?Reveals?Spatial

?GenomeDisorganization?Associated?with?

Copy?Number?Variations

Cheng?Li

?(Peking?University)

Weijun?Feng

(FudanUniversity）

A?novel?RNA?epigenetic?mechanism:?

m6A?RNA-mediated?celldamage?response

Chih-Hung?Hsu

（ZhejiangUniverisity）

VI.?Developmental?Epigenetics

Chair?of?the?first?half?part:?Guoliang?Xu

(Academia?Sinica,Shanghai)

Moshe?Szyf

（Canada，?McGillUniversity?）

Single-cell?multi-omics?sequencing?of?

mouse?early?embryosandembryonic?stem?cells

Fuchou?Tang

(PekingUniversity)

Chromatin?Accessibility?Landscape?in?

Human?Early?Embryos?andIts?Association?with?Evolution

Lei?Gao

（Academia?Sinica,Beijing）

Dnmt2?mediates?intergenerational?transmission?of?

paternallyacquired?metabolic?disorders?through?

sperm?small?non-codingRNAs

Yunfang?Zhang

（The?ThirdMilitary?Medical?University）

lncRNA-MIR100HG?derived?miR-100?and?miR-125b?

mediatecetuximab?resistance?via?Wnt/β-catenin?signaling?in?colorectalcancer

Yuanyuan?Lu

（The?FourthMilitary?Medical?University）

Stella?safeguards?the?oocyte?methylome?by

?preventing?excessivede?novo?methylation?

mediated?by?DNMT1

Zhuqiang?Zhang

（AcademiaSinica）

Tea?Break

Chair?of?the?second?half?part:?Xiangdong?Fu(UCSD)

Spatio-temporal?dynamics?of?chromatin?in?

developmentalhematopoietic?cells?initiating

?the?oncogenic?alterations

Dengli?Hong

（Shanghai?JiaoTong?

University?School?ofMedicine）

MAnorm2:?quantitative?comparison?of?ChIP-seq?samplesongroup?level?to?identify?sex-biased?histone?modification?sites

Small?Molecule-induced?Cell?Fate?Reprogramming

Closing